翻訳と辞書 ・ N,N-Diisopropylaminoethanol ・ N,N-Diisopropylethylamine ・ N,N-Dimethyl-1-naphthylamine ・ N,N-Dimethyldopamine ・ N,N-Dimethylethylamine ・ N,N-dimethylformamidase ・ N,N-Dimethylsphingosine ・ N,N-Dimethyltryptamine ・ N,N′-Dimethyl-1,3-propanediamine ・ N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate ・ N,O-Dimethylhydroxylamine ・ N- ・ N-(1-Naphthyl)ethylenediamine ・ N-(2-Hydroxypropyl) methacrylamide ・ N-(long-chain-acyl)ethanolamine deacylase ・ N-(p-amylcinnamoyl)anthranilic acid ・ N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide ・ N-105 National Highway ・ N-110 National Highway ・ N-110 road (Spain) ・ N-111 road (Spain) ・ N-113 road (Spain) ・ N-120 National Highway ・ N-120 road (Spain) ・ N-121 road (Spain) ・ N-122 road (Spain) ・ N-123 road (Spain) ・ N-124 road (Spain) ・ N-125 National Highway ・ N-135 road (Spain)
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N-(p-amylcinnamoyl)anthranilic acid : ウィキペディア英語版 | N-(p-amylcinnamoyl)anthranilic acid
N-(p-amylcinnamoyl)anthranilic acid (ACA) is a modulator of various ion channels in the heart. N-(p-amylcinnamoyl)anthranilic acid is an effective reversible inhibitor of calcium-activated chloride channels and, to a lesser extent, cAMP-activated chloride channels, without affecting L-type calcium channels.〔Gwanyanya A, Macianskiene R, Bito V, Sipido KR, Vereecke J, Mubagwa K. "Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA)". ''Biochem Biophys Res Commun'' 2010;402:531–536.〕 Calcium-activated chloride channels are believed to be involved in developing arrhythmia.〔〔Verkerk A, Veldkamp M, Bouman L, van Ginneken A. "Calcium-Activated Cl− Current Contributes to Delayed After depolarizations in Single Purkinje and Ventricular Myocytes". ''Circulation'' 2000;101:2639–2644.〕 == Arrhythmia ==
Arrhythmia is a cardiac disease which is characterized by an irregular heartbeat. Some forms of arrhythmia are dangerous and life-threatening, while others are comparably minor. Heart cells (cardiac myocytes) contract due to an increase in the charge across the membrane (depolarization), which generates an action potential. Irregular contractions can cause arrhythmia to occur.〔〔Guyton A, Hall J. ''Textbook of Medical Physiology'', Tenth Ed. Philadelphia, PA:W.B. Saunders Company, 2000.〕
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